Nature Communications (Aug 2020)

Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention

  • Jack D. Adderley,
  • Simona John von Freyend,
  • Sarah A. Jackson,
  • Megan J. Bird,
  • Amy L. Burns,
  • Burcu Anar,
  • Tom Metcalf,
  • Jean-Philippe Semblat,
  • Oliver Billker,
  • Danny W. Wilson,
  • Christian Doerig

DOI
https://doi.org/10.1038/s41467-020-17829-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Plasmodium infection activates signaling pathways in a-nucleated erythrocytes. Here, Adderley et al. use a comprehensive antibody microarray to show that infection extensively modulates host cell signalling and that the host receptor tyrosine kinase c-MET supports Plasmodium falciparum proliferation.