2.3 PULSE WAVE VELOCIY IN A LARGE POPULATIONAL STUDY. PRELIMINARY RESULTS BRAZILIAN LONGITUDINAL STUDY OF ADULT HEALTH (ELSA-BRASIL)

Abstract

Large artery stiffening is widely accepted as a determinant of ISH in the population with a predictive power of CV events has been shown to be beyond traditional risk scores. However, its clinical role in is still limited perhaps due to the lack of established reference values and methodological uniformity. The aim of this prospective longitudinal study is to investigate the role of large artery stiffening as determinant of cardiovascular disease. ELSA-Brazil is a cohort study of 15,105 university servants, aged 35–74 years. The baseline examination was carried out from 2008 through 2010 and included interviews, clinical, anthropometric examinations, overnight urine, ECG, IMT, echocardiography, retinography, HR variability, and PWV (Complior). All centres were submitted to a central training and validation. A biologic sample was stored to allow investigation of biomarkers of CV risk. Values are mean ±SD. PWV measurements were obtained in 14,835 individuals (M:F; 6,780:8,055). PWV is strongly influenced by age and BP (R2 = 0,41). HR and fasting glucose provides only additional 2% in R2 change. Lipids were not correlated to PWV. Age and BP adjusted values in men are higher than in women (9,53 ± 1,89 vs 9,2 ± 1,88 m/s, P < 0,001), but the slope of correlation with age are not different. BP status does not change the correlation of BP and PWV. However adjusted PWV values are increased in Diabetic individuals (9,97 ± 2,3 vs 9,18 ± m/s,P < 0,001). The present study has a potential to clarify important questions regarding the role of PWV as a determinant of disease, favouring its routine inclusion in clinical practice.