Frontiers in Genetics (May 2020)

Immune-Related Prognostic Model in Colon Cancer: A Gene Expression-Based Study

  • Haojie Yang,
  • Wei Jin,
  • Hua Liu,
  • Dan Gan,
  • Can Cui,
  • Changpeng Han,
  • Zhenyi Wang

DOI
https://doi.org/10.3389/fgene.2020.00401
Journal volume & issue
Vol. 11

Abstract

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Mounting evidence supports that the malignant phenotypes of cancers are defined not only by the intrinsic activity of tumor cells but also by immune cells that are recruited and activated in tumor-related microenvironment. Here, we developed a diagnostic and prognostic model for colon cancer, based on expression profiles of immune-related genes and immune cell component. As a result, we found that B cell infiltration ratio, CD4+ T cells, as well as immune-related genes of TRIB3, CHGA, CASP7, LGALS4, LEP, NOX4, IL17A, and HSPD1 may be highly relevant with clinical outcome of colon cancer.

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