Monogenetic osteoporosis: Does the risk of fall matter?

Abstract

We introduce an adult male case report with a history of osteogenesis imperfecta related fractures without specific medication against osteoporosis until the age of 50 years; however, within the first year he was offered anti-osteoporotic medication, he suffered a fall and a consecutive fracture was registered despite improved of bone mineral density parameters at DXA (dual-energy x-ray absorptiometry), proving the importance of life style intervention to minimize the dramatic impact on bone fragility due to a genetic condition. Despite the fact that the risk of fracture on a subject with a genetic condition that directly impacts the bone status represents a game changer, the everyday circumstantial situations that cause an increased risk of fall represent strong players that need to be taken into consideration as part of patients’ education.

Keywords

• osteoporosis
• osteogenesis imperfecta
• risk of fall
• fracture
• dxa
• endocrine osteoporosis
• male osteoporosis
• collagen
• bone mineral density
• z-score