Preclinical data on co-delivery of temozolomide and talazoparib by fucodain-coated nanoscale metal organic frameworks for colorectal cancer chemoradiation
Allison N. DuRoss,
Madeleine R. Landry,
Charles R. Thomas, Jr.,
Megan J. Neufeld,
Conroy Sun
Affiliations
Allison N. DuRoss
Department of Pharmaceutical Sciences, Oregon State University, 2730 SW Moody Ave, Portland, OR 97201, USA
Madeleine R. Landry
Department of Pharmaceutical Sciences, Oregon State University, 2730 SW Moody Ave, Portland, OR 97201, USA
Charles R. Thomas, Jr.
Department of Radiation Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA; Radiation Oncology, Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center, One Medical Center Drive, Lebanon, NH 03756, USA
Megan J. Neufeld
Department of Pharmaceutical Sciences, Oregon State University, 2730 SW Moody Ave, Portland, OR 97201, USA
Conroy Sun
Department of Pharmaceutical Sciences, Oregon State University, 2730 SW Moody Ave, Portland, OR 97201, USA; Department of Radiation Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA; Corresponding author at: Department of Pharmaceutical Sciences, Oregon State University, 2730 SW Moody Ave, Portland, OR 97201-5041, USA.
Nanoparticle characterization and in vitro data on the effects of combined PARP inhibition and DNA damage by chemoradiation are shown. This data accompanies the research article “Fucoidan-coated nanoparticles target radiation-induced P-selectin to enhance chemoradiotherapy in murine colorectal cancer” (DuRoss et al., 2021) Additional characterization of the physiochemical properties of nanoscale metal organic frameworks (nMOFs) comprised of hafnium and 1,4-dicarboxybenzene (Hf-BDC) loaded with temozolomide (TMZ) and talazoparib (Tal) are presented. Toxicity data of the drug-loaded nMOF coated with fucoidan (TT@Hf-BDC-Fuco) in colorectal cancer cells, CT-26, from alamarBlue-based chemoradiation experiments are shown. Experimental methods for the nanoparticle characterization and cell-based assays of the nMOF formulation are presented.
