Frontiers in Public Health (May 2022)

Incidence, Risk Factors and Outcomes of Sepsis in Critically Ill Post-craniotomy Patients: A Single-Center Prospective Cohort Study

  • Jianfang Zhou,
  • Xu-Ying Luo,
  • Guang-Qiang Chen,
  • Hong-Liang Li,
  • Ming Xu,
  • Shuai Liu,
  • Yan-Lin Yang,
  • Guangzhi Shi,
  • Jian-Xin Zhou,
  • Linlin Zhang

DOI
https://doi.org/10.3389/fpubh.2022.895991
Journal volume & issue
Vol. 10

Abstract

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BackgroundData concerning the epidemiology of sepsis in critically ill post-craniotomy patients are scarce. This study aimed to assess the incidence, risk factors, and outcomes of sepsis in this population.MethodsThis was a single-center prospective cohort study. Post-craniotomy patients admitted to the intensive care unit (ICU) were screened daily for the presence of infection and sepsis.ResultsOf the 900 included patients, 300 developed sepsis. The cumulative incidence of sepsis was 33.3% [95% confidence interval (CI), 30.2–36.4%]. Advanced age, male, hypertension, trauma, postoperative intracranial complications, and lower Glasgow Coma Scale (GCS) on the first postoperative day were independent risk factors of sepsis. Septic patients had higher hospital mortality (13.7 vs. 8.3%, P = 0.012), longer ICU length of stay (LOS) (14 vs. 4 days, P < 0.001), longer hospital LOS (31 vs. 19 days, P < 0.001), and higher total medical cost (CNY 138,394 vs. 75,918, P < 0.001) than patients without sepsis.ConclusionSepsis is a frequent complication in critically ill post-craniotomy patients. Advanced age, male, hypertension, trauma, postoperative intracranial complications, and lower GCS on the first postoperative day were independent risk factors of sepsis.

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