Open Medicine
(Feb 2022)
Smurf2 suppresses the metastasis of hepatocellular carcinoma via ubiquitin degradation of Smad2
Song Dongqiang,
Li Shuyu,
Ning Liuxin,
Zhang Shuncai,
Cai Yu
Affiliations
Song Dongqiang
Liver Cancer Institute, Zhongshan Hospital of Fudan University, Xuhui District, Shanghai, P. R. China
Li Shuyu
Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, Xuhui District, Shanghai, P. R. China
Ning Liuxin
Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, Xuhui District, Shanghai, P. R. China
Zhang Shuncai
Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, Xuhui District, Shanghai, P. R. China
Cai Yu
Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, Xuhui District, Shanghai, P. R. China
DOI
https://doi.org/10.1515/med-2022-0437
Journal volume & issue
Vol. 17,
no. 1
Abstract
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Smurf2, one of C2-WW-HECT domain E3 ubiquitin ligases, is closely related to the development and progression in different cancer types, including hepatocellular carcinoma (HCC). This study aims to illustrate the expression and molecular mechanism of Smurf2 in regulating the progression of HCC.
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