Smurf2 suppresses the metastasis of hepatocellular carcinoma via ubiquitin degradation of Smad2

Song Dongqiang; Li Shuyu; Ning Liuxin; Zhang Shuncai; Cai Yu

doi:10.1515/med-2022-0437

Open Medicine (Feb 2022)

Smurf2 suppresses the metastasis of hepatocellular carcinoma via ubiquitin degradation of Smad2

Song Dongqiang,
Li Shuyu,
Ning Liuxin,
Zhang Shuncai,
Cai Yu

Affiliations

Song Dongqiang: Liver Cancer Institute, Zhongshan Hospital of Fudan University, Xuhui District, Shanghai, P. R. China
Li Shuyu: Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, Xuhui District, Shanghai, P. R. China
Ning Liuxin: Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, Xuhui District, Shanghai, P. R. China
Zhang Shuncai: Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, Xuhui District, Shanghai, P. R. China
Cai Yu: Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, Xuhui District, Shanghai, P. R. China

DOI: https://doi.org/10.1515/med-2022-0437
Journal volume & issue: Vol. 17, no. 1
pp. 384 – 396

Abstract

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Smurf2, one of C2-WW-HECT domain E3 ubiquitin ligases, is closely related to the development and progression in different cancer types, including hepatocellular carcinoma (HCC). This study aims to illustrate the expression and molecular mechanism of Smurf2 in regulating the progression of HCC.

Published in Open Medicine

ISSN: 2391-5463 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine
Website: https://www.degruyter.com/journal/key/med/html

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