Twelve Hours Post-Injection Serum Human Chorionic Gonadotropin and Body Mass Index Predicts In Vitro Fertilization Oocyte Maturation Rate: A Cross-Sectional Study

Abstract

Background: In vitro fertilization (IVF) remains a main treatment for infertility cases. Post-injection human chorionic gonadotropin(hCG) level is an essential factor in determining oocyte maturation rate in IVF. This study aimed to determine therelationship between 12 hours post-injection serum hCG level and oocyte maturation rate among IVF participants.Materials and Methods: A cross-sectional study on IVF participants was done at a tertiary hospital in Indonesia fromJanuary 2020 to December 2021. Subjects were injected with 250 μg of recombinant-hCG (r-hCG) subcutaneously.Twelve hours post-injection serum hCG levels and oocyte maturation rate data were retrieved and analyzed accordingly.Results: Twenty-eight subjects were recruited into the study. Higher 12 hours post-injection serum hCG was relatedto oocyte maturation rate (P=0.046). The cut-off point of 12 hours post-injection serum hCG to predict better oocytematuration rate was 90.15 mIU/mL (sensitivity 68.2%, specificity 83.3%). Oocyte maturation rate may be predictedusing body mass index (BMI) and 12 hours post-injection serum hCG.Conclusion: Higher 12 hours post-injection serum hCG was associated with a higher oocyte maturation rate in IVFsubjects.

Keywords

• human chorionic gonadotropin hormone
• in vitro fertilization
• oocyte
• oocyte maturation