Nature Communications (Mar 2023)

Neuraminidase 1 promotes renal fibrosis development in male mice

  • Qian-Qian Chen,
  • Kang Liu,
  • Ning Shi,
  • Gaoxiang Ma,
  • Peipei Wang,
  • Hua-Mei Xie,
  • Si-Jia Jin,
  • Ting-Ting Wei,
  • Xiang-Yu Yu,
  • Yi Wang,
  • Jun-Yuan Zhang,
  • Ping Li,
  • Lian-Wen Qi,
  • Lei Zhang

DOI
https://doi.org/10.1038/s41467-023-37450-8
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 20

Abstract

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The influenza virus neuraminidase has been well documented, yet the functions of mammalian neuraminidases remain less explored. Here, the authors show that neuraminidase 1 promotes renal fibrosis development by interacting with ALK5 to activate SMAD2/3.