NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines

Yuli He; Huayue Song; Jian Chen; Shaolin Zhu

doi:10.1038/s41467-020-20888-5

Nature Communications (Jan 2021)

NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines

Yuli He,
Huayue Song,
Jian Chen,
Shaolin Zhu

Affiliations

Yuli He: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University
Huayue Song: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University
Jian Chen: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University
Shaolin Zhu: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University

DOI: https://doi.org/10.1038/s41467-020-20888-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 7

Abstract

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Chiral benzylamines are found in many pharmacologically active molecules. Here, the authors report an enantio- and regio-selective reductive hydroarylation of N-acyl enamines with a NiH/chiral bis-imidazoline catalytic system affording a range of enantioenriched benzylamines.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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