Pediatric Rheumatology Online Journal (Jan 2022)
Proteomics based markers of clinical pain severity in juvenile idiopathic arthritis
- Hanne Van Der Heijden,
- Benoit Fatou,
- Diana Sibai,
- Kacie Hoyt,
- Maria Taylor,
- Kin Cheung,
- Jordan Lemme,
- Mariesa Cay,
- Benjamin Goodlett,
- Jeffery Lo,
- Melissa M. Hazen,
- Olha Halyabar,
- Esra Meidan,
- Rudy Schreiber,
- Camilo Jaimes,
- Kirsten Ecklund,
- Lauren A. Henderson,
- Margaret H. Chang,
- Peter A. Nigrovic,
- Robert P. Sundel,
- Hanno Steen,
- Jaymin Upadhyay
Affiliations
- Hanne Van Der Heijden
- Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School
- Benoit Fatou
- Department of Pathology, Boston Children’s Hospital, Harvard Medical School
- Diana Sibai
- Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School
- Kacie Hoyt
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Maria Taylor
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Kin Cheung
- BioSAS Consulting, Inc
- Jordan Lemme
- Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School
- Mariesa Cay
- Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School
- Benjamin Goodlett
- Division of Genetics and Genomics, Boston Children’s Hospital, Harvard Medical School
- Jeffery Lo
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Melissa M. Hazen
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Olha Halyabar
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Esra Meidan
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Rudy Schreiber
- Faculty of Psychology and Neuroscience, Section Neuropsychology & Psychopharmacology Maastricht University
- Camilo Jaimes
- Department of Radiology, Boston Children’s Hospital, Harvard Medical School
- Kirsten Ecklund
- Department of Radiology, Boston Children’s Hospital, Harvard Medical School
- Lauren A. Henderson
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Margaret H. Chang
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Peter A. Nigrovic
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Robert P. Sundel
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Hanno Steen
- Department of Pathology, Boston Children’s Hospital, Harvard Medical School
- Jaymin Upadhyay
- Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1186/s12969-022-00662-1
- Journal volume & issue
-
Vol. 20,
no. 1
pp. 1 – 10
Abstract
Highlights In the current preliminary study, serum proteins associated with pain severity were identified in JIA patients. Pain-associated proteins had functional roles predominantly in immune or inflammatory processes. Correlations of pain-associated proteins with ESR and altered CNS morphology were also observed with ESR and altered CNS morphology were also observed. Larger-scale as well as longitudinal studies are needed to determine if evaluation of the proteome may provide a platform for identifying novel analgesic targets in JIA.
Keywords
