Novel Analytical Workflow for Comprehensive Non-targeted Phytochemical Metabolic Profiling
Timm Hettich,
Götz Schlotterbeck
Affiliations
Timm Hettich
University of Applied Sciences, Northwestern Switzerland, School of Life Sciences, Institute for Chemistry and Bioanalytics, Gründenstrasse 40, CH-4132 Muttenz, Switzerland
Götz Schlotterbeck
University of Applied Sciences, Northwestern Switzerland, School of Life Sciences, Institute for Chemistry and Bioanalytics, Gründenstrasse 40, CH-4132 Muttenz, Switzerland. [email protected]
The understanding and interpretation of pharmacological properties on a molecular level is of great importance for many different fields of research. Our study provides a novel model work-flow for comprehensive metabolic profiling by structural identification of relevant metabolites not limited to phytochemistry applications. High resolution liquid chromatography mass spectrometry LC-MS/MS data can be directly correlated with pharmacological test results on a molecular level. Thus the understanding and interpretation of pharmacological properties is supported by structural and chemical information.
