Nature Communications (Nov 2019)
Transcriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase associated with Charcot-Marie-Tooth neuropathy
- Sven Bervoets,
- Na Wei,
- Maria-Luise Erfurth,
- Shazie Yusein-Myashkova,
- Biljana Ermanoska,
- Ligia Mateiu,
- Bob Asselbergh,
- David Blocquel,
- Priyanka Kakad,
- Tyrone Penserga,
- Florian P Thomas,
- Velina Guergueltcheva,
- Ivailo Tournev,
- Tanja Godenschwege,
- Albena Jordanova,
- Xiang-Lei Yang
Affiliations
- Sven Bervoets
- Molecular Neurogenomics Group, VIB-UAntwerp Center for Molecular Neurology, University of Antwerp
- Na Wei
- Department of Molecular Medicine, The Scripps Research Institute
- Maria-Luise Erfurth
- Molecular Neurogenomics Group, VIB-UAntwerp Center for Molecular Neurology, University of Antwerp
- Shazie Yusein-Myashkova
- Molecular Neurogenomics Group, VIB-UAntwerp Center for Molecular Neurology, University of Antwerp
- Biljana Ermanoska
- Molecular Neurogenomics Group, VIB-UAntwerp Center for Molecular Neurology, University of Antwerp
- Ligia Mateiu
- VIB-UAntwerp Center for Molecular Neurology, University of Antwerp
- Bob Asselbergh
- VIB-UAntwerp Center for Molecular Neurology, University of Antwerp
- David Blocquel
- Department of Molecular Medicine, The Scripps Research Institute
- Priyanka Kakad
- Department of Biological Sciences, Florida Atlantic University
- Tyrone Penserga
- Department of Biological Sciences, Florida Atlantic University
- Florian P Thomas
- Hereditary Neuropathy Foundation Center of Excellence, Department of Neurology, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack University Medical Center
- Velina Guergueltcheva
- Clinic of Neurology, University Hospital Sofiamed, Sofia University St. Kliment Ohridski
- Ivailo Tournev
- Clinic of Neurological Diseases, UMBAL Aleksandrovska, Department of Neurology, Medical University-Sofia
- Tanja Godenschwege
- Department of Biological Sciences, Florida Atlantic University
- Albena Jordanova
- Molecular Neurogenomics Group, VIB-UAntwerp Center for Molecular Neurology, University of Antwerp
- Xiang-Lei Yang
- Department of Molecular Medicine, The Scripps Research Institute
- DOI
- https://doi.org/10.1038/s41467-019-12909-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Tyrosyl-tRNA synthetase (TyrRS) is a translation factor and predominantly cytoplasmic, but can also be found in the nucleus. Here authors show using a fly model of Charcot-Marie-Tooth (CMT) disease that nuclear localization of mutant TyrRS contributes to the CMT-like phenotype.
