White matter hyperintensities are more highly associated with preclinical Alzheimer's disease than imaging and cognitive markers of neurodegeneration

Benjamin M. Kandel; Brian B. Avants; James C. Gee; Corey T. McMillan; Guray Erus; Jimit Doshi; Christos Davatzikos; David A. Wolk; Alzheimer's Disease Neuroimaging Initiative

doi:10.1016/j.dadm.2016.03.001

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring (Jan 2016)

White matter hyperintensities are more highly associated with preclinical Alzheimer's disease than imaging and cognitive markers of neurodegeneration

Benjamin M. Kandel,
Brian B. Avants,
James C. Gee,
Corey T. McMillan,
Guray Erus,
Jimit Doshi,
Christos Davatzikos,
David A. Wolk,
Alzheimer's Disease Neuroimaging Initiative

Affiliations

Benjamin M. Kandel: Penn Image Computing and Science Laboratory and Department of BioengineeringUniversity of PennsylvaniaPhiladelphiaPAUSA
Brian B. Avants: Penn Image Computing and Science Laboratory and Department of RadiologyPerelman School of Medicine, University of PennsylvaniaPhiladelphiaPAUSA
James C. Gee: Penn Image Computing and Science Laboratory and Department of RadiologyPerelman School of Medicine, University of PennsylvaniaPhiladelphiaPAUSA
Corey T. McMillan: Department of NeurologyPerelman School of Medicine, University of PennsylvaniaPhiladelphiaPAUSA
Guray Erus: Center for Biomedical Image Computing and Analytics, University of PennsylvaniaPhiladelphiaPA
Jimit Doshi: Center for Biomedical Image Computing and Analytics, University of PennsylvaniaPhiladelphiaPA
Christos Davatzikos: Center for Biomedical Image Computing and Analytics, University of PennsylvaniaPhiladelphiaPA
David A. Wolk: Department of NeurologyPerelman School of Medicine, University of PennsylvaniaPhiladelphiaPAUSA
Alzheimer's Disease Neuroimaging Initiative: Penn Image Computing and Science Laboratory and Department of BioengineeringUniversity of PennsylvaniaPhiladelphiaPAUSA

DOI: https://doi.org/10.1016/j.dadm.2016.03.001
Journal volume & issue: Vol. 4, no. 1
pp. 18 – 27

Abstract

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Abstract Introduction Cognitive tests and nonamyloid imaging biomarkers do not consistently identify preclinical AD. The objective of this study was to evaluate whether white matter hyperintensity (WMH) volume, a cerebrovascular disease marker, is more associated with preclinical AD than conventional AD biomarkers and cognitive tests. Methods Elderly controls enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI, n = 158) underwent florbetapir‐PET scans, psychometric testing, neuroimaging with MRI and PET, and APOE genetic testing. Elderly controls the Parkinson's progression markers initiative (PPMI, n = 58) had WMH volume, cerebrospinal fluid (CSF) Aβ1–42, and APOE status measured. Results In the ADNI cohort, only WMH volume and APOE ε4 status were associated with cerebral Aβ (standardized β = 0.44 and 1.25, P = .03 and .002). The association between WMH volume and APOE ε4 status with cerebral Aβ (standardized β = 1.12 and 0.26, P = .048 and .045) was confirmed in the PPMI cohort. Discussion WMH volume is more highly associated with preclinical AD than other AD biomarkers.

Published in Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

ISSN: 2352-8729 (Online)
Publisher: Wiley
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system; Medicine: Internal medicine: Special situations and conditions: Geriatrics
Website: https://alz-journals.onlinelibrary.wiley.com/journal/23528729

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Abstract

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