Improving the effectiveness of the skin integrity restoring after deep burns by platelet-enriched plasma application

Abstract

Objective. To study the effectiveness of platelet-enriched plasma application in patients with deep burns at the stage of wounds preparation for autodermoplasty. Materials and methods. The study was performed on 23 patients with burns IIA, IIB and III degrees taking 25 - 40% of the body surface. Comprehensive local treatment of patients of the main group included injection of platelet-enriched plasma at the stage of preparation of postoperative wounds for autodermoplasty. In patients of the control group, local treatment was limited by dressings with antiseptic solution. Examination of patients included visual inspection of the damaged area, microbiological examination of wound contents and histological examination of damaged tissues. Results. Applying the suggested method of burn wounds local treatment resulted in reducing time of wounds preparation for closure by autologous skin grafts, reducing of their healing period, decreasing of tissues inflammatory activity, blood flow improvement, and stimulating processes of tissue granulation, proliferation, epithelialization. Conclusions. The application of the autologous platelet-enriched plasma can be considered as an effective biotechnology that can increase the effectiveness of the skin integrity restoring in patients with burns.

Keywords

• burns; platelet-enriched plasma; wound healing; autodermoplasty.