Frontiers in Genetics (Jun 2013)
The UGT1A6_19_GG genotype is a breast cancer risk factor
- Christina eJustenhoven,
- Ofure eObazee,
- Stefan eWinter,
- Sylvia eRabstein,
- Anne eLotz,
- Volker eHarth,
- Beate ePesch,
- Thomas eBruening,
- Christian eBaisch,
- Jaana M Hartikainen,
- Arto eMannermaa,
- Veli-Matti eKosma,
- Vesa eKataja,
- Robert eWinqvist,
- Katri ePylkaes,
- Arja eJukkola-Vuorinen,
- Mervi eGrip,
- Peter eFasching,
- Matthias eBeckmann,
- Arif B Ekici,
- Alexander eHein,
- Per eHall,
- Jingmei eLi,
- Jenny eChang-Claude,
- Dieter eFlesch-Janys,
- Petra eSeibold,
- Anja eRudolph,
- Ute eHamann,
- Yon-Dschun eKo,
- Hiltrud eBrauch
Affiliations
- Christina eJustenhoven
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
- Ofure eObazee
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
- Stefan eWinter
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
- Sylvia eRabstein
- Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)
- Anne eLotz
- Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)
- Volker eHarth
- Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)
- Beate ePesch
- Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)
- Thomas eBruening
- Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)
- Christian eBaisch
- Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus
- Jaana M Hartikainen
- University of Eastern Finland
- Arto eMannermaa
- University of Eastern Finland
- Veli-Matti eKosma
- University of Eastern Finland
- Vesa eKataja
- University of Eastern Finland
- Robert eWinqvist
- University of Oulu
- Katri ePylkaes
- University of Oulu
- Arja eJukkola-Vuorinen
- University of Oulu
- Mervi eGrip
- University of Oulu
- Peter eFasching
- University of Erlangen
- Matthias eBeckmann
- University of Erlangen
- Arif B Ekici
- University of Erlangen
- Alexander eHein
- University of Erlangen
- Per eHall
- Karolinska Intitute
- Jingmei eLi
- genome Institute of Singapore
- Jenny eChang-Claude
- German Cancer Research Center (DKFZ)
- Dieter eFlesch-Janys
- University Medical Center Hamburg-Eppendorf
- Petra eSeibold
- German Cancer Research Center (DKFZ)
- Anja eRudolph
- German Cancer Research Center (DKFZ)
- Ute eHamann
- German Cancer Research Center (DKFZ)
- Yon-Dschun eKo
- Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus
- Hiltrud eBrauch
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
- DOI
- https://doi.org/10.3389/fgene.2013.00104
- Journal volume & issue
-
Vol. 4
Abstract
Validation of an association between the UGT1A6_19_T>G (rs6759892) polymorphism and overall breast cancer risk. A pilot study included two population-based case-control studies from Germany (MARIE-GENICA). An independent validation study comprised four independent breast cancer case-control studies from Finland (KBCP, OBCS), Germany (BBCC) and Sweden (SASBAC). The pooled analysis included 7,418 cases and 8,720 controls from all six studies. Participants were of European descent. Genotyping was done by MALDI-TOF MS and statistical analysis was performed by logistic regression adjusted for age and study. The increased overall breast cancer risk for women with the UGT1A6_19_GG genotype which was observed in the pilot study was confirmed in the set of four independent study collections (OR 1.13, 95% CI 1.05-1.22; p = 0.001). The pooled study showed a similar effect (OR 1.09, 95% CI 1.04-1.14; p = 0.001). We confirmed the association of UGT1A6_19_GG with increased overall breast cancer risk and conclude that our result from a well powered multi-stage study adds a novel candidate to the panel of validated breast cancer susceptibility loci.
Keywords
