TNIK signaling imprints CD8+ T cell memory formation early after priming

Carla A. Jaeger-Ruckstuhl; Magdalena Hinterbrandner; Sabine Höpner; Colin E. Correnti; Ursina Lüthi; Olivier Friedli; Stefan Freigang; Mohamad F. Al Sayed; Elias D. Bührer; Michael A. Amrein; Christian M. Schürch; Ramin Radpour; Carsten Riether; Adrian F. Ochsenbein

doi:10.1038/s41467-020-15413-7

Nature Communications (Apr 2020)

TNIK signaling imprints CD8+ T cell memory formation early after priming

Carla A. Jaeger-Ruckstuhl,
Magdalena Hinterbrandner,
Sabine Höpner,
Colin E. Correnti,
Ursina Lüthi,
Olivier Friedli,
Stefan Freigang,
Mohamad F. Al Sayed,
Elias D. Bührer,
Michael A. Amrein,
Christian M. Schürch,
Ramin Radpour,
Carsten Riether,
Adrian F. Ochsenbein

Affiliations

Carla A. Jaeger-Ruckstuhl: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern
Magdalena Hinterbrandner: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern
Sabine Höpner: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern
Colin E. Correnti: Clinical Research Division, Fred Hutchinson Cancer Research Center (FHCRC)
Ursina Lüthi: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern
Olivier Friedli: Graduate School of Cellular and Biomedical Sciences, University of Bern
Stefan Freigang: Institute of Pathology, University of Bern
Mohamad F. Al Sayed: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern
Elias D. Bührer: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern
Michael A. Amrein: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern
Christian M. Schürch: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern
Ramin Radpour: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern
Carsten Riether: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern
Adrian F. Ochsenbein: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern

DOI: https://doi.org/10.1038/s41467-020-15413-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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Coordinate expression of multiple factors play critical roles in the regulation between effector and memory CD8+ T cell differentiation. Here the authors show upon acute viral infection TNIK is critically required as a regulator of effector and memory T cell differentiation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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