Tyrosine phosphorylation of the GARU E3 ubiquitin ligase promotes gibberellin signalling by preventing GID1 degradation

Keiichirou Nemoto; Abdelaziz Ramadan; Gen-ichiro Arimura; Kenichiro Imai; Kentaro Tomii; Kazuo Shinozaki; Tatsuya Sawasaki

doi:10.1038/s41467-017-01005-5

Nature Communications (Oct 2017)

Tyrosine phosphorylation of the GARU E3 ubiquitin ligase promotes gibberellin signalling by preventing GID1 degradation

Keiichirou Nemoto,
Abdelaziz Ramadan,
Gen-ichiro Arimura,
Kenichiro Imai,
Kentaro Tomii,
Kazuo Shinozaki,
Tatsuya Sawasaki

Affiliations

Keiichirou Nemoto: Proteo-Science Center (PROS), Ehime University
Abdelaziz Ramadan: Proteo-Science Center (PROS), Ehime University
Gen-ichiro Arimura: Faculty of Industrial Science & Technology, Department of Biological Science & Technology, Tokyo University of Science
Kenichiro Imai: Artificial Intelligence Research Center (AIRC) and Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST)
Kentaro Tomii: Artificial Intelligence Research Center (AIRC) and Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST)
Kazuo Shinozaki: Gene Discovery Research Group, RIKEN Center for Sustainable Resource Science
Tatsuya Sawasaki: Proteo-Science Center (PROS), Ehime University

DOI: https://doi.org/10.1038/s41467-017-01005-5
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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Plants respond to gibberellins via GID1-dependent degradation of DELLA proteins. Here, Nemoto et al. show that the gibberellin response is positively regulated by tyrosine phosphorylation of GARU, an E3 ubiquitin ligase that mediates degradation of GID1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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