Different scan areas affect the detection rates of diabetic retinopathy lesions by high-speed ultra-widefield swept-source optical coherence tomography angiography

Mengyu Li; Mengyu Li; Mengyu Li; Mingzhu Mao; Mingzhu Mao; Mingzhu Mao; Dingyang Wei; Dingyang Wei; Dingyang Wei; Miao Liu; Miao Liu; Miao Liu; Xinyue Liu; Xinyue Liu; Xinyue Liu; Hongmei Leng; Hongmei Leng; Hongmei Leng; Yiya Wang; Yiya Wang; Yiya Wang; Sizhu Chen; Sizhu Chen; Sizhu Chen; Ruifan Zhang; Ruifan Zhang; Yong Zeng; Yong Zeng; Min Wang; Jie Li; Jie Li; Jie Zhong; Jie Zhong

doi:10.3389/fendo.2023.1111360

Frontiers in Endocrinology (Feb 2023)

Different scan areas affect the detection rates of diabetic retinopathy lesions by high-speed ultra-widefield swept-source optical coherence tomography angiography

Mengyu Li,
Mengyu Li,
Mengyu Li,
Mingzhu Mao,
Mingzhu Mao,
Mingzhu Mao,
Dingyang Wei,
Dingyang Wei,
Dingyang Wei,
Miao Liu,
Miao Liu,
Miao Liu,
Xinyue Liu,
Xinyue Liu,
Xinyue Liu,
Hongmei Leng,
Hongmei Leng,
Hongmei Leng,
Yiya Wang,
Yiya Wang,
Yiya Wang,
Sizhu Chen,
Sizhu Chen,
Sizhu Chen,
Ruifan Zhang,
Ruifan Zhang,
Yong Zeng,
Yong Zeng,
Min Wang,
Jie Li,
Jie Li,
Jie Zhong,
Jie Zhong

Affiliations

Mengyu Li: Department of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Mengyu Li: Department of Ophthalmology, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China
Mengyu Li: Eye School, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Mingzhu Mao: Department of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Mingzhu Mao: Department of Ophthalmology, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China
Mingzhu Mao: School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
Dingyang Wei: Department of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Dingyang Wei: Department of Ophthalmology, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China
Dingyang Wei: School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
Miao Liu: Department of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Miao Liu: Department of Ophthalmology, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China
Miao Liu: Eye School, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Xinyue Liu: Department of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Xinyue Liu: Department of Ophthalmology, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China
Xinyue Liu: Eye School, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Hongmei Leng: Department of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Hongmei Leng: Department of Ophthalmology, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China
Hongmei Leng: School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
Yiya Wang: Department of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Yiya Wang: Department of Ophthalmology, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China
Yiya Wang: School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
Sizhu Chen: Department of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Sizhu Chen: Department of Ophthalmology, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China
Sizhu Chen: Eye School, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Ruifan Zhang: Department of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Ruifan Zhang: Department of Ophthalmology, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China
Yong Zeng: Department of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Yong Zeng: Department of Ophthalmology, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China
Min Wang: Department of Ophthalmology, Dayi Shaoxiang Hospital, Chengdu, China
Jie Li: Department of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Jie Li: Department of Ophthalmology, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China
Jie Zhong: Department of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Jie Zhong: Department of Ophthalmology, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China

DOI: https://doi.org/10.3389/fendo.2023.1111360
Journal volume & issue: Vol. 14

Abstract

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IntroductionThe study aimed to determine the effect of the scanning area used for high-speed ultra-widefield swept-source optical coherence tomography angiography (SS-OCTA) on the detection rate of diabetic retinopathy (DR) lesions.MethodsThis prospective, observational study involved diabetic patients between October 2021 and April 2022. The participants underwent a comprehensive ophthalmic examination and high-speed ultra-widefield SS-OCTA using a 24 mm × 20 mm scanning protocol. A central area denoted as “12 mm × 12 mm-central” was extracted from the 24 mm × 20 mm image, and the remaining area was denoted as “12 mm~24mm-annulus.” The rates of detection of DR lesions using the two scanning areas were recorded and compared.ResultsIn total, 172 eyes (41 eyes with diabetes mellitus without DR, 40 eyes with mild to moderate non-proliferative diabetic retinopathy (NPDR), 51 eyes with severe NPDR, and 40 eyes with proliferative diabetic retinopathy (PDR) from 101 participants were included. The detection rates of microaneurysms (MAs), intraretinal microvascular abnormalities (IRMAs), and neovascularization (NV) for the 12 mm × 12 mm central and 24 mm × 20 mm images were comparable (p > 0.05). The detection rate of NPAs for the 24 mm × 20 mm image was 64.5%, which was significantly higher than that for the 12 mm × 12 mm central image (52.3%, p < 0.05). The average ischemic index (ISI) was 15.26% for the 12 mm~24mm-annulus, which was significantly higher than that for the 12 mm × 12 mm central image (5.62%). Six eyes had NV and 10 eyes had IRMAs that only existed in the 12 mm~24mm-annulus area.ConclusionsThe newly developed high-speed ultra-widefield SS-OCTA can capture a 24 mm × 20 mm retinal vascular image during a single scan, which improves the accuracy of detecting the degree of retinal ischemia and detection rate of NV and IRMAs.

Published in Frontiers in Endocrinology

ISSN: 1664-2392 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.frontiersin.org/journals/endocrinology

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