Nature Communications (May 2021)

Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences

  • K. Shaw,
  • L. Bell,
  • K. Boyd,
  • D. M. Grijseels,
  • D. Clarke,
  • O. Bonnar,
  • H. S. Crombag,
  • C. N. Hall

DOI
https://doi.org/10.1038/s41467-021-23508-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

Read online

The hippocampus is particularly sensitive to hypoxia but it has been difficult to study blood flow in this region. Here the authors compare the neurovascular function of the hippocampus and cortex and in awake mice, and find differences associated with microvascular structure.