Communications Biology (Jan 2023)

Optogenetic and pharmacological interventions link hypocretin neurons to impulsivity in mice

  • Susan M. Tyree,
  • Kimberly J. Jennings,
  • Oscar C. Gonzalez,
  • Shi-bin Li,
  • Janet R. Nicholson,
  • Moritz von Heimendahl,
  • Luis de Lecea

DOI
https://doi.org/10.1038/s42003-023-04409-w
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 8

Abstract

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Optogenetic or pharmacological modulation of hypocretin neurons impacts mouse impulsivity in a Go/No-Go task, suggesting that these neurons play a key role in integrating salient stimuli and guiding responses to various environmental cues.