Selection of the R263K and H51Y resistance substitutions for DTG causes diminished integration and explains the lack of clinically significant drug resistance to this compound

• Thibault Mesplède,
• Jiaming Liang,
• Katlin Anstett,
• Nathan Osman,
• Hanh Thi Pham,
• Mark A. Wainberg

Affiliations

Thibault Mesplède

Jewish General Hospital, McGill AIDS Center, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada

Jiaming Liang

Jewish General Hospital, McGill AIDS Center, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada

Katlin Anstett

Jewish General Hospital, McGill AIDS Center, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada

Nathan Osman

Jewish General Hospital, McGill AIDS Center, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada

Hanh Thi Pham

Jewish General Hospital, McGill AIDS Center, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada

Mark A. Wainberg

Jewish General Hospital, McGill AIDS Center, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada