Effect of Nizatidine on Renal Ischemia-Reperfusion Damage

Abstract

INTRODUCTION: The first intervention needed for ischaemic tissue is to restore blood flow. However, the abundant molecular oxygen that is supplied to the ischaemic tissue via arterial blood after reperfusion results in the formation of excessive free oxygen radicals and oxidative stress. This suggests a potential benefit from treatment with antioxidants for reducing the ischaemia-reperfusion (I/R) damage. In our study, we investigated the effect of nizatidine, an H2 receptor antagonist antiulcer drug for the treatment of peptic ulcers, on renal I/R damage. The cytoprotective effect of nizatidine is known to originate from its antioxidant characteristics. No information was found in the literature regarding the protective effect of nizatidine on renal I/R damage. The objective of this study was to investigate the effect of nizatidine on oxidative renal damage induced in rats by I/R. METHODS: In this study, albino Wistar male rats were grouped into renal ischaemia-reperfusion (RIR), nizatidine 50 mg/kg + renal ischaemia-reperfusion (NIR-50), and sham surgery (SG) conditions. RESULTS: Our biochemical test results showed that oxidative stress markers, such as malondialdehyde (MDA) and myeloperoxidase (MPO), increased significantly (p<0.0001) in the renal tissue of the RIR group with I/R, compared with the SG group, while endogenous antioxidants, such as superoxide dismutase (SOD) and glutathione peroxidase (GPO), decreased significantly (p<0.0001). Nizatidine significantly attenuated the increases in MDA and MPO in kidney tissue and the decreases in SOD and GPO (p<0.0001). DISCUSSION AND CONCLUSION: Our results demonstrate that nizatidine protects kidney tissue against I/R injury

Keywords

• nizatidine
• kidney
• ischaemia
• reperfusion.