Active iodine regulated in cow dung biochar-based hydrogel combined with PDT/PTT for MRSA infected wound therapy

Qinggele Borjihan; Suriguga Meng; Haoran Bai; Ting Chen; Xinshang Hu; Douxin Xiao; Lan Shi; Alideertu Dong

Materials & Design (Jul 2023)

Active iodine regulated in cow dung biochar-based hydrogel combined with PDT/PTT for MRSA infected wound therapy

Qinggele Borjihan,
Suriguga Meng,
Haoran Bai,
Ting Chen,
Xinshang Hu,
Douxin Xiao,
Lan Shi,
Alideertu Dong

Affiliations

Qinggele Borjihan: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China; Engineering Research Center of Dairy Quality and Safety Control Technology, Ministry of Education, Inner Mongolia University, Hohhot 010021, China; Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, Inner Mongolia, China
Suriguga Meng: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China; Engineering Research Center of Dairy Quality and Safety Control Technology, Ministry of Education, Inner Mongolia University, Hohhot 010021, China
Haoran Bai: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China; Engineering Research Center of Dairy Quality and Safety Control Technology, Ministry of Education, Inner Mongolia University, Hohhot 010021, China
Ting Chen: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China; Engineering Research Center of Dairy Quality and Safety Control Technology, Ministry of Education, Inner Mongolia University, Hohhot 010021, China
Xinshang Hu: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China; Engineering Research Center of Dairy Quality and Safety Control Technology, Ministry of Education, Inner Mongolia University, Hohhot 010021, China
Douxin Xiao: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China; Engineering Research Center of Dairy Quality and Safety Control Technology, Ministry of Education, Inner Mongolia University, Hohhot 010021, China; Corresponding authors at: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China.
Lan Shi: College of Science, Inner Mongolia Agricultural University, Hohhot 010018, China; Corresponding authors at: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China.
Alideertu Dong: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China; Engineering Research Center of Dairy Quality and Safety Control Technology, Ministry of Education, Inner Mongolia University, Hohhot 010021, China; Corresponding authors at: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China.

Journal volume & issue: Vol. 231
p. 112051

Abstract

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Iodine has been successed in combating bacteria over a century, but its toxic effects on human skin tissues and cells have been overlooked. In this work, a cow dung biochar-based polyvinyl alcohol/polyvinylpyrrolidone hydrogel (BCPP) was designed to in situ produce iodine on-demand and regulate its release via the light triggering strategy for the infected wound therapy. Benefiting from the reactive oxygen species (ROS) generation and the photothermal conversion properties of cow dung biochar (BC), the as-prepared hydrogel in situ transformed iodide into active iodine under the visible (Vis) light irradiation and regulated the release of active iodine under the near-infrared (NIR) light irradiation. The active iodine combined with photodynamic and photothermal effects of BCPP endowed hydrogel excellent antibacterial effects on ampicillin-resistant Escherichia coli (AREC) and methicillin-resistant Staphylococcus aureus (MRSA) while showing low toxicity to the mammalian cells. The in vivo wound therapy test results demonstrated that this hydrogel resisted MRSA infection, accelerated the healing process, and promoted epithelial regeneration.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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