Nature Communications (Apr 2020)
Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts
- Kwanghee Kim,
- Wenhuo Hu,
- François Audenet,
- Nima Almassi,
- Aphrothiti J. Hanrahan,
- Katie Murray,
- Aditya Bagrodia,
- Nathan Wong,
- Timothy N. Clinton,
- Shawn Dason,
- Vishnu Mohan,
- Sylvia Jebiwott,
- Karan Nagar,
- Jianjiong Gao,
- Alex Penson,
- Chris Hughes,
- Benjamin Gordon,
- Ziyu Chen,
- Yiyu Dong,
- Philip A. Watson,
- Ricardo Alvim,
- Arijh Elzein,
- Sizhi P. Gao,
- Emiliano Cocco,
- Alessandro D. Santin,
- Irina Ostrovnaya,
- James J. Hsieh,
- Irit Sagi,
- Eugene J. Pietzak,
- A. Ari Hakimi,
- Jonathan E. Rosenberg,
- Gopa Iyer,
- Herbert A. Vargas,
- Maurizio Scaltriti,
- Hikmat Al-Ahmadie,
- David B. Solit,
- Jonathan A. Coleman
Affiliations
- Kwanghee Kim
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Wenhuo Hu
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- François Audenet
- Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- Nima Almassi
- Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- Aphrothiti J. Hanrahan
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Katie Murray
- Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- Aditya Bagrodia
- Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- Nathan Wong
- Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- Timothy N. Clinton
- Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- Shawn Dason
- Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- Vishnu Mohan
- Department of Biological Regulation, Weizmann Institute of Science
- Sylvia Jebiwott
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Karan Nagar
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Jianjiong Gao
- Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Alex Penson
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Chris Hughes
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Benjamin Gordon
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Ziyu Chen
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Yiyu Dong
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Philip A. Watson
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Ricardo Alvim
- Department of Surgery, Memorial Sloan Kettering Cancer Center
- Arijh Elzein
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Sizhi P. Gao
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Emiliano Cocco
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Alessandro D. Santin
- Gynecology & Reproductive Sciences, Department of Obstetrics, Yale University School of Medicine
- Irina Ostrovnaya
- Department of Epidemiology-Biostatistics, Memorial Sloan Kettering Cancer Center
- James J. Hsieh
- Molecular Oncology, Department of Medicine, Siteman Cancer Center, Washington University
- Irit Sagi
- Department of Biological Regulation, Weizmann Institute of Science
- Eugene J. Pietzak
- Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- A. Ari Hakimi
- Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- Jonathan E. Rosenberg
- Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Gopa Iyer
- Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Herbert A. Vargas
- Body Imaging Service, Department of Radiology, Memorial Sloan Kettering Cancer Center
- Maurizio Scaltriti
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Hikmat Al-Ahmadie
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- David B. Solit
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Jonathan A. Coleman
- Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- DOI
- https://doi.org/10.1038/s41467-020-15885-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
The advancement of upper tract urothelial carcinoma (UTUC) research is hampered by the lack of disease-specific models. Here, the authors report patient derived xenograft and cell line models of UTUC, and show that these models retain the genomic and biological heterogeneity of human disease.
