Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain

Abstract

During Drosophila development, two peaks of Notch activity propagate across the neuroepithelium to generate neuroblasts. Here, the authors show Notch cis-inhibition under the control of intracellular Notch trafficking establishes these two peaks, which temporally control neurogenesis in the brain.