European Journal of Breast Health (Apr 2022)

Impact of Detection Mode in a Large Cohort of Women Taking Part in a Breast Screening Program

  • Marilina García,
  • Maximino Redondo,
  • Irene Zarcos,
  • Javier Louro,
  • Francisco Rivas-Ruiz,
  • Teresa Téllez,
  • Diego Pérez,
  • Francisco Medina Cano,
  • Kenza Machan,
  • Laia Domingo,
  • Maria del Mar Vernet,
  • Maria Padilla-Ruiz,
  • Xavier Castells,
  • Maria Sala

DOI
https://doi.org/10.4274/ejbh.galenos.2022.2021-11-8
Journal volume & issue
Vol. 18, no. 2
pp. 182 – 189

Abstract

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Objective:The aim of this study was to evaluate the existing survival rate and clinical-pathological differences among patients with breast cancer detected by mammographic screening.Materials and Methods:This multicenter cohort study examined 1,248 patients who took part in a national screening program for the early detection of breast cancer over an eight-year period.Results:Of the two patient subgroups (interval and screening), we found significant differences in the distribution of prognostic factors, with interval cases presenting at a lower mean age (p = 0.002), with higher percentages of human epidermal growth factor receptor 2 (HER-2) or triple negative and lower percentages of luminal A or luminal B carcinomas (p = 0.001), advanced stages (p<0.001), lower hormone receptor expression (p<0.001), poorer differentiation (p<0.001) and lower survival (p<0.001). Among the screening group, patients with tumors detected during the first screening round had a significantly lower mean age (p<0.001), a lower frequency of comorbidities (p = 0.038) and a lower tendency (p<0.1) to be diagnosed as triple negative breast carcinomas than incident cases.Conclusion:Our results highlight that breast tumors detected during the first screening round are frequently characterized by a more benign phenotype than the rest of the screening subgroups, which could be of help when stratifying the risk of death and selecting the best treatment option for each patient.

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