Gynecology and Minimally Invasive Therapy (Aug 2017)

Complete androgen insensitivity syndrome and anti-Müllerian hormone levels before and after laparoscopic gonadectomy

  • Maki Kusumi,
  • Makiko Mitsunami,
  • Hiroki Onoue,
  • Momo Noma,
  • Fumiko Matsumura,
  • Chisa Tabata,
  • Seiji Tanaka,
  • Noriko Watanabe,
  • Takako Kurosawa,
  • Toshihiro Fujiwara,
  • Osamu Tsutusmi

DOI
https://doi.org/10.1016/j.gmit.2016.11.001
Journal volume & issue
Vol. 6, no. 3
pp. 126 – 128

Abstract

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We report cases of two sisters with complete androgen insensitivity syndrome (CAIS). A complete female appearance, blind-ending vagina, and testes in the pelvis are characteristics of CAIS. Prophylactic laparoscopic gonadectomy was performed in both cases. Anti-Müllerian hormone (AMH) level is known to be very high in patients with CAIS; AMH is secreted by Sertoli cells and testosterone suppresses the secretion. In our cases, serum AMH was very high before gonadectomy and dramatically decreased after gonadectomy. AMH could be the diagnostic feature for patients with CAIS.

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