FEATURES OF CELLULAR AND HUMORAL IMMUNITY IN PATIENTS WITH EXTENSIVE PURULENT PERITONITIS

Abstract

We investigated immunological parameters in patients with extensive purulent peritonitis (EPP). It is established that the EPP revealed an imbalance in the immune system which is characterized by a deficiency of cellular part and increased activity of the humoral. Status of cellular immunity is determined by the decrease in the EPP number of T- (primarily through fractions of cytotoxic T-lymphocytes and expressing of late activation. marker), NK- and NKT-cells. In the peripheral blood of patients with EPP increases the content of Th-cells and B1-lymphocytes. Status humoral immunity in the EPP is characterized by increased Ig A and Ig G levels. With the help of correlation analysis and the separate definition of the entropy of the lymphocytes phenotypic composition and immunoglobulins found an increase in regulatory effect on the humoral immunity.

Keywords

• peritonitis
• lymphocytes
• immunoglobulins