Nature Communications (Jun 2021)
Genome sequencing unveils a regulatory landscape of platelet reactivity
- Ali R. Keramati,
- Ming-Huei Chen,
- Benjamin A. T. Rodriguez,
- Lisa R. Yanek,
- Arunoday Bhan,
- Brady J. Gaynor,
- Kathleen Ryan,
- Jennifer A. Brody,
- Xue Zhong,
- Qiang Wei,
- NHLBI Trans-Omics for Precision (TOPMed) Consortium,
- Kai Kammers,
- Kanika Kanchan,
- Kruthika Iyer,
- Madeline H. Kowalski,
- Achilleas N. Pitsillides,
- L. Adrienne Cupples,
- Bingshan Li,
- Thorsten M. Schlaeger,
- Alan R. Shuldiner,
- Jeffrey R. O’Connell,
- Ingo Ruczinski,
- Braxton D. Mitchell,
- Nauder Faraday,
- Margaret A. Taub,
- Lewis C. Becker,
- Joshua P. Lewis,
- Rasika A. Mathias,
- Andrew D. Johnson
Affiliations
- Ali R. Keramati
- Division of Cardiology, Johns Hopkins University School of Medicine
- Ming-Huei Chen
- Division of Intramural Research, Population Sciences Branch, National Heart, Lung and Blood Institute
- Benjamin A. T. Rodriguez
- Division of Intramural Research, Population Sciences Branch, National Heart, Lung and Blood Institute
- Lisa R. Yanek
- GeneSTAR Research Program, Johns Hopkins University School of Medicine
- Arunoday Bhan
- Boston Children’s Hospital
- Brady J. Gaynor
- Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine
- Kathleen Ryan
- Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine
- Jennifer A. Brody
- Cardiovascular Health Research Unit, University of Washington School of Medicine
- Xue Zhong
- Vanderbilt Genetics Institute, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center
- Qiang Wei
- Vanderbilt Genetics Institute, Department of Molecular Physiology and Biophysics, Vanderbilt University
- NHLBI Trans-Omics for Precision (TOPMed) Consortium
- Vanderbilt Genetics Institute, Department of Molecular Physiology and Biophysics, Vanderbilt University
- Kai Kammers
- Biostatistics and Bioinformatics, Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Kanika Kanchan
- Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine
- Kruthika Iyer
- Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine
- Madeline H. Kowalski
- Department of Biostatistics, University of North Carolina
- Achilleas N. Pitsillides
- The Framingham Heart Study
- L. Adrienne Cupples
- The Framingham Heart Study
- Bingshan Li
- Vanderbilt Genetics Institute, Department of Molecular Physiology and Biophysics, Vanderbilt University
- Thorsten M. Schlaeger
- Boston Children’s Hospital
- Alan R. Shuldiner
- Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore
- Jeffrey R. O’Connell
- Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine
- Ingo Ruczinski
- Bloomberg School of Public Health, Biostatistics, Johns Hopkins University
- Braxton D. Mitchell
- Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine
- Nauder Faraday
- GeneSTAR Research Program, Johns Hopkins University School of Medicine
- Margaret A. Taub
- Bloomberg School of Public Health, Biostatistics, Johns Hopkins University
- Lewis C. Becker
- Division of Cardiology, Johns Hopkins University School of Medicine
- Joshua P. Lewis
- Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine
- Rasika A. Mathias
- GeneSTAR Research Program, Johns Hopkins University School of Medicine
- Andrew D. Johnson
- Division of Intramural Research, Population Sciences Branch, National Heart, Lung and Blood Institute
- DOI
- https://doi.org/10.1038/s41467-021-23470-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Platelet aggregation is associated with myocardial infarction and stroke. Here, the authors have conducted a whole genome sequencing association study on platelet aggregation, discovering a locus in RGS18, where enhancer assays suggest an effect on activity of haematopoeitic lineage transcription factors.
