INFLUENCE OF PROPHYLACTIC PENTAHYDRATE OF SELENIT OF SODIUM ON THE FREQUENCY OF THE DEVELOPMENT OF BACTERIAL SEPSIS AT FULL-TERM NEWBORN BABIES WITH THE RESPIRATORY DISTRESS SYNDROME AND THE CEREBRAL ISCHEMIA, BEING ON AVL

Abstract

Purpose: the aim of the study was to improve the results of treatment of the full-term babies with SDR and cerebral ischemia, being on AVL, connected with a decrease of the incidence of bacterial complications, by using sodium selenite pentahydrate.Materials and methods: controlled randomized blind clinical test of application of sodium selenite pentahydrate at newborns with RDS and the cerebral ischemia being on the artificial ventilation of lungs (AVL) was carried out. 76 newborn children being in a critical condition were surveyed. Randomization was carried out by a method of the computer program of a random number generator. In I group (n=36), entered sodium selenite pentahydrate in a dose of 10 mkg/kg/days intravenously slowly, within 10 days, II group (n=40) – group of control.Results: sepsis as a complication of the underlying disease, developed in 11 (14,5%) patients from 76 patients included in the study. Moreover, in group I (treated by selenase) sepsis occurred in 2 (5,5%) infants, while in group two II, in 9 (22,5%) patients.Summary: thus, in our study conclusive, statistically significant evidence was obtained that, using sodium selenite pentahydrate is not only a significant decrease (4.5-fold) (p < 0.05).

Keywords

• selenium, sepsis (sirs), respiratory distress syndrome of newborns