³¹Р NMR spectroscopy of high resolution in metabolomic analysis of oral liquid

Abstract

Being one of the main tools in metabolomics, NMR spectroscopy has a growing importance in medicine and in dentistry. Dental hard tissue resistance to destruction has a correlation with the level of phosphorus content in saliva. Clinical examination of patients, men and women, aged from 18 to 30 years, was carried out. Particular attention was paid to the detection of wedge-shaped defects of teeth hard tissues at various stages of this disease and to the co-factors of its occurrence. NMR spectroscopy of phosphorus isotope (31Р) nuclei of oral liquid samples from a healthy person (control) and patients with severe wedge-shaped lesions was chosen as a laboratory testing method. These data show that the saliva (PO4)n- groups are the part of liquid filmic polymer structures of different thickness, with the thickness of the control sample films is greater than that of ill patients’ samples.

Keywords

• клиновидные дефекты
• метаболомика
• молодые пациенты
• резистентность твердых тканей
• ротовая жидкость
• ямр-спектроскопия
• hard tissue resistance
• metabolomics
• nmr spectroscopy
• oral liquid
• wedge-shaped lesions
• young patients