Nature Communications (Mar 2018)
A systematic approach to the development of a safe live attenuated Zika vaccine
- Swee Sen Kwek,
- Satoru Watanabe,
- Kuan Rong Chan,
- Eugenia Z. Ong,
- Hwee Cheng Tan,
- Wy Ching Ng,
- Mien T. X. Nguyen,
- Esther S. Gan,
- Summer L. Zhang,
- Kitti W. K. Chan,
- Jun Hao Tan,
- October M. Sessions,
- Menchie Manuel,
- Julien Pompon,
- Camillus Chua,
- Sharifah Hazirah,
- Karl Tryggvason,
- Subhash G. Vasudevan,
- Eng Eong Ooi
Affiliations
- Swee Sen Kwek
- Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
- Satoru Watanabe
- Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
- Kuan Rong Chan
- Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
- Eugenia Z. Ong
- Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
- Hwee Cheng Tan
- Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
- Wy Ching Ng
- Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
- Mien T. X. Nguyen
- Programme in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School
- Esther S. Gan
- Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
- Summer L. Zhang
- Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
- Kitti W. K. Chan
- Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
- Jun Hao Tan
- Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
- October M. Sessions
- Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
- Menchie Manuel
- Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
- Julien Pompon
- Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
- Camillus Chua
- SingHealth Translational Immunology and Inflammation Centre, SingHealth
- Sharifah Hazirah
- SingHealth Translational Immunology and Inflammation Centre, SingHealth
- Karl Tryggvason
- Programme in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School
- Subhash G. Vasudevan
- Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
- Eng Eong Ooi
- Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
- DOI
- https://doi.org/10.1038/s41467-018-03337-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
A Zika virus (ZIKV) vaccine should provide long-lasting immunity, which may be achieved with a live-attenuated vaccine. Here, Kwek et al. select an interferon-restricted, attenuated ZIKV variant and evaluate replication and immunogenicity in mouse and mosquito models.
