Сеченовский вестник (Dec 2022)

Vitamins and carotenoids in the dynamics of prostate gland oncogenesis

  • P. V. Glybochko,
  • E. G. Zezerov,
  • Yu. G. Alyaev,
  • V. B. Spirichev,
  • D. V. Butnaru,
  • S. E. Severin,
  • A. Z. Vinarov,
  • N. A. Beketova,
  • O. G. Pereverzeva,
  • V. A. Varshavsky,
  • E. V. Osipov,
  • E. A. Bezrukov

Journal volume & issue
Vol. 0, no. 3-4
pp. 4 – 13

Abstract

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The content of vitamins and relative biologically active substances including the products of lipids peroxidation has been studied in the blood of 115 males -patients of Department of Urology of I.M.Sechenov First Moscow State Medical University. The patients have been divided to four groups: prostatic carcinoma (PC); high grade prostatic intraepithelial neoplasia (HG PIN) or precancer; mixed group of conditional control – low grade PIN, benign prostatic hyperplasia, chronic prostatitis or their combination; control group of healthy men without prostate pathology. Further statistically reliable differences have been found: patients with PC had lower level of antioxidants – lycopene, vitamin E and enhanced level of diene conjugates (products of lipid peroxidation); patients with HG PIN low level of vitamin C, total carotenoids and increased diene conjugates. The difference in vitamins-antioxidants levels in patients with PC and HG PIN has not been found out.

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