Compulsive alcohol drinking in rodents is associated with altered representations of behavioral control and seeking in dorsal medial prefrontal cortex

Nicholas M. Timme; Baofeng Ma; David Linsenbardt; Ethan Cornwell; Taylor Galbari; Christopher C. Lapish

doi:10.1038/s41467-022-31731-4

Nature Communications (Jul 2022)

Compulsive alcohol drinking in rodents is associated with altered representations of behavioral control and seeking in dorsal medial prefrontal cortex

Nicholas M. Timme,
Baofeng Ma,
David Linsenbardt,
Ethan Cornwell,
Taylor Galbari,
Christopher C. Lapish

Affiliations

Nicholas M. Timme: Psychology Department, Indiana University—Purdue University Indianapolis
Baofeng Ma: Psychology Department, Indiana University—Purdue University Indianapolis
David Linsenbardt: Department of Neurosciences, University of New Mexico
Ethan Cornwell: Psychology Department, Indiana University—Purdue University Indianapolis
Taylor Galbari: Psychology Department, Indiana University—Purdue University Indianapolis
Christopher C. Lapish: Psychology Department, Indiana University—Purdue University Indianapolis

DOI: https://doi.org/10.1038/s41467-022-31731-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

Read online

Compulsive alcohol drinking is a core feature of alcohol use disorder. Here the authors find that in rodents, neural signals in a key decision-making brain region (dmPFC) shift from behavioral control to alcohol seeking during compulsive alcohol drinking behaviour.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal