Killer Cell Immunoglobulin-like Receptor Genotypes and Reproductive Outcomes in a Group of Infertile Women: A Romanian Study
Mihai Surcel,
Iulia Adina Neamtiu,
Daniel Muresan,
Iulian Goidescu,
Adelina Staicu,
Monica Mihaela Marta,
Georgiana Nemeti,
Radu Harsa,
Bogdan Doroftei,
Mihai Emil Capilna,
Gabriela Caracostea
Affiliations
Mihai Surcel
1st Department of Obstetrics and Gynecology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 3-5 Clinicilor Street, 400347 Cluj-Napoca, Romania
Iulia Adina Neamtiu
Health Department, Environmental Health Center, Part of ALS, 58 Busuiocului Street, 400240 Cluj-Napoca, Romania
Daniel Muresan
1st Department of Obstetrics and Gynecology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 3-5 Clinicilor Street, 400347 Cluj-Napoca, Romania
Iulian Goidescu
1st Department of Obstetrics and Gynecology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 3-5 Clinicilor Street, 400347 Cluj-Napoca, Romania
Adelina Staicu
1st Department of Obstetrics and Gynecology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 3-5 Clinicilor Street, 400347 Cluj-Napoca, Romania
Monica Mihaela Marta
Department of Medical Education, “Iuliu Hatieganu” University of Medicine and Pharmacy, 3-5 Clinicilor Street, 400347 Cluj-Napoca, Romania
Georgiana Nemeti
1st Department of Obstetrics and Gynecology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 3-5 Clinicilor Street, 400347 Cluj-Napoca, Romania
Radu Harsa
In Vitro fertilization Department, “Regina Maria” Hospital, 29 Dorobantilor Street, 400117 Cluj-Napoca, Romania
Bogdan Doroftei
Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania
Mihai Emil Capilna
1st Department of Obstetrics and Gynecology, University of Medicine, Pharmacy Science and Technology “George Emil Palade”, 38 Gheorghe Marinescu, 540142 Targu Mures, Romania
Gabriela Caracostea
1st Department of Obstetrics and Gynecology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 3-5 Clinicilor Street, 400347 Cluj-Napoca, Romania
A growing body of evidence suggests that endometrial immune disorders may be responsible for endometrial dysfunctions that can lead to gynecological and obstetrical pathology. The aim of this study was to explore the potential relationship between different killer cell immunoglobulin-like receptor (KIR) genotypes and reproductive outcomes. We conducted a prospective cohort study that included 104 infertile patients undergoing an in vitro fertilization procedure. All participants underwent clinical and ultrasound examination, genetic evaluation (KIR genotyping), endometrial washing fluid sampling for cytokine determination, endometrial tissue sampling for histologic assessment and hysteroscopic evaluation. Our analysis showed statistically significant lower levels of uterine cytokines TNF-α (p = 0.001) and IL-1beta (p = 0.000) in the KIR AA genotype group as compared to KIR AB and BB among study participants with chronic endometritis. The study results suggest that the KIR AA genotype population subgroups may be more susceptible to developing endometrial disorders such as chronic endometritis. The changes in the behavior of NK cells seem to be subtle and expressed as an altered regulatory pattern.
