Mediterranean Journal of Hematology and Infectious Diseases (Feb 2018)

Association of the SOD2 polymorphism (Val6Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia

  • Isabela Cristina Cordeiro Farias,
  • Taciana Furtado Mendonça-Belmont,
  • Andreia Soares Silva,
  • Kleyton Palmeira do Ó,
  • Felipe Borba Ferreira,
  • Fernanda Silva Medeiros,
  • Luydson Richardson Silva Vasconcelos,
  • Moacyr Jesus Barreto de Melo Rego,
  • Marcos Andre Cavalcanti Bezerra,
  • Aderson Silva Araujo,
  • Patricia Muniz Mendes Freire Moura,
  • Ana Claudia Mendonça Anjos,
  • Betânia Lucena Domingues Hatzlhofer,
  • Maria do Socorro Mendonça Cavalcanti

DOI
https://doi.org/10.4084/mjhid.2018.012
Journal volume & issue
Vol. 10, no. 1
pp. e2018012 – e2018012

Abstract

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The SOD2 polymorphism Val16Ala TàC influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children aged 1-9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (p=0.0321; p=0.0253, respectively). Furthermore, TC/CC were more frequent in patients with VOC or ASS (p=0.0285; p=0.0090, respectively). These results suggest that the SOD2 polymorphism associated with low SOD activity could be involved in SCA physiopathology.

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