Precise identification of cancer cells from allelic imbalances in single cell transcriptomes

Affiliations

Mi K. Trinh: Wellcome Sanger Institute, Wellcome Genome Campus
Clarissa N. Pacyna: Wellcome Sanger Institute, Wellcome Genome Campus
Gerda Kildisiute: Wellcome Sanger Institute, Wellcome Genome Campus
Christine Thevanesan: University College London Great Ormond Street Institute of Child Health
Alice Piapi: University College London Great Ormond Street Institute of Child Health
Kirsty Ambridge: Wellcome Sanger Institute, Wellcome Genome Campus
Nathaniel D. Anderson: Wellcome Sanger Institute, Wellcome Genome Campus
Eleonora Khabirova: Wellcome Sanger Institute, Wellcome Genome Campus
Elena Prigmore: Wellcome Sanger Institute, Wellcome Genome Campus
Karin Straathof: University College London Great Ormond Street Institute of Child Health
Sam Behjati: Wellcome Sanger Institute, Wellcome Genome Campus
Matthew D. Young: Wellcome Sanger Institute, Wellcome Genome Campus

Abstract

The identification of cancer cells from single cell transcriptomes can be improved by detecting allelic imbalances due to copy number changes.