Current Issues in Pharmacy and Medical Sciences (Dec 2020)
The effect of Ketogenic diet on vitamin D3 and testosterone hormone in patients with diabetes mellitus type 2
Abstract
A keto diet is well-known for being a low carb diet in which the body produces ketones in the liver to be used as energy. When something high in carbs is eaten, the body will produce glucose and insulin. Glucose is the easiest molecule for the body to convert and use as energy, so it will be chosen over any other energy source. The aim of this study is to examine the effect of a ketogenic diet on type 2 diabetic patients and the effect it has on testosterone, vitamin D3, HDL, LDL levels, in comparison to non-ketogenic diet subjects. In the study, Type 2 diabetic patients undergoing a keto diet were selected and serum D3 levels and testosterone levels were examined and compared with control subjects. The result show a significant increase in testosterone hormone in patients with diabetes mellitus type 2 following a Ketogenic diet (mean± Std. Error 427.4±2.52) as compared with the control group (mean ± Std. Error 422.2±0.24) and as compared with patients with diabetes mellitus type 2 who are not following a Ketogenic diet (mean± Std. Error 151.4±1.41). The results show no significant level in LDL level in patients with diabetes mellitus type 2 following a Ketogenic diet (mean ± Std. Error 78.53±0.17), as compared to a control group (mean ± Std. Error 75.0.3±0.14) and no significant level in HDL level in patients with diabetes mellitus type 2 following a Ketogenic diet (mean± Std. Error 46.3±1.55), as compared with a control group (mean ± Std. Error 46.2±2.43), and with patients with diabetes mellitus type 2 who are not following a Ketogenic diet (mean ± Std. Error 45.1±1.55). The results show a significant increase in vitamin D3 level in patient with diabetes mellitus type 2 who are following a Ketogenic diet (mean ± Std. Error 53.5±0.32), as compared with a control group (mean± Std. Error 57±0.24), and with patients with diabetes mellitus type 2 who are not following a Ketogenic diet (mean ± Std. Error 25.1±1.55). Herein, normal vitamin D3 levels in patients corresponds to normal testosterone hormone levels. In conclusion, this study shows that in patients with diabetes mellitus type 2, following a ketogenic diet has a positive effect on the patients’ health.
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