Therapeutic potential of gene therapy for gastrointestinal diseases: Advancements and future perspectives

Ning-ning Yue; Hao-ming Xu; Jing Xu; Min-zheng Zhu; Yuan Zhang; Cheng-Mei Tian; Yu-qiang Nie; Jun Yao; Yu-jie Liang; De-feng Li; Li-sheng Wang

Molecular Therapy: Oncolytics (Sep 2023)

Therapeutic potential of gene therapy for gastrointestinal diseases: Advancements and future perspectives

Ning-ning Yue,
Hao-ming Xu,
Jing Xu,
Min-zheng Zhu,
Yuan Zhang,
Cheng-Mei Tian,
Yu-qiang Nie,
Jun Yao,
Yu-jie Liang,
De-feng Li,
Li-sheng Wang

Affiliations

Ning-ning Yue: Department of Gastroenterology, Shenzhen People’s Hospital (the Second Clinical Medical College, Jinan University), Shenzhen 518000, China
Hao-ming Xu: Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou 510000, China
Jing Xu: Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou 510000, China
Min-zheng Zhu: Department of Gastroenterology and Hepatology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510000, China
Yuan Zhang: Department of Medical Administration, Huizhou Institute of Occupational Diseases Control and Prevention, Huizhou, Guangdong 516000, China
Cheng-Mei Tian: Department of Emergency, Shenzhen People’s Hospital (the Second Clinical Medical College, Jinan University, the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518000, China
Yu-qiang Nie: Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou 510000, China
Jun Yao: Department of Gastroenterology, Shenzhen People’s Hospital (the Second Clinical Medical College, Jinan University, the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518000, China
Yu-jie Liang: Department of Child and Adolescent Psychiatry, Shenzhen Kangning Hospital, Shenzhen 518000, China; Corresponding author: Yu-jie Liang, Department of Child and Adolescent Psychiatry, Shenzhen Kangning Hospital, Shenzhen 518000, China.
De-feng Li: Department of Gastroenterology, Shenzhen People’s Hospital (the Second Clinical Medical College, Jinan University, the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518000, China; Corresponding author: De-feng Li, Department of Gastroenterology, Shenzhen People’s Hospital (the Second Clinical Medical College, Jinan University, the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518000, China.
Li-sheng Wang: Department of Gastroenterology, Shenzhen People’s Hospital (the Second Clinical Medical College, Jinan University, the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518000, China; Corresponding author: Li-sheng Wang, Department of Gastroenterology, Shenzhen People’s Hospital (the Second Clinical Medical College, Jinan University, the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518000, China.

Journal volume & issue: Vol. 30
pp. 193 – 215

Abstract

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Advancements in understanding the pathogenesis mechanisms underlying gastrointestinal diseases, encompassing inflammatory bowel disease, gastrointestinal cancer, and gastroesophageal reflux disease, have led to the identification of numerous novel therapeutic targets. These discoveries have opened up exciting possibilities for developing gene therapy strategies to treat gastrointestinal diseases. These strategies include gene replacement, gene enhancement, gene overexpression, gene function blocking, and transgenic somatic cell transplantation. In this review, we introduce the important gene therapy targets and targeted delivery systems within the field of gastroenterology. Furthermore, we provide a comprehensive overview of recent progress in gene therapy related to gastrointestinal disorders and shed light on the application of innovative gene-editing technologies in treating these conditions. These developments are fueling a revolution in the management of gastrointestinal diseases. Ultimately, we discuss the current challenges (particularly regarding safety, oral efficacy, and cost) and explore potential future directions for implementing gene therapy in the clinical settings for gastrointestinal diseases.

Published in Molecular Therapy: Oncolytics

ISSN: 2372-7705 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.cell.com/molecular-therapy-family/oncolytics/latest-content

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