Journal of Medicinal Plants (Dec 2009)

Zebra Fish: Technology for Natural Product Discovery

  • R Hajiaghaee,
  • Z Bagherzadeh,
  • B Zarea,
  • MA Faramarzi,
  • AR Shahverdi

Journal volume & issue
Vol. 8, no. 32
pp. 14 – 24

Abstract

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Rising challenges in the present drug discovery model are prompting Prompt a renewed interest in natural products as a source of novel, bioactive small molecules. With the current validation of zebra fish as a biomedical appropriate model for functional genomics and in vivo drug discovery, the zebra fish bioassay-guided identification of natural products may be an attractive tactic to generate new lead compounds in a number of indication regions. Here, we review recent natural product research using zebra fish and evaluate the potential of this vertebrate model as a discovery platform for the systematic identification of bioactive natural products.

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