INTERLEUKIN 10, BODY MASS INDEX AND SERUM ALBUMIN IN CHRONIC KIDNEY DISEASE STAGE 5D PATIENTS

Abstract

IL-10 - one of the central factors in the altered cytokine network of uremia, may play important role in the development of T-helper imbalance, CVD and wasting in dialysis patients. Aim: to evaluate level of ІL-10 in CKD stage 5D patients depending on the body mass index and serum albumin. Methods: Thirty-nine HD patients were included (male/female 20/19, age 21- 53 years, mean dialysis treatment time 4.2 ± 1.21 years). Blood tests were taken before a midweek dialysis session. Serum IL-10, serum albumin and BMI were measured. Results: HD patients had higher serum IL-10 than healthy donors (79.9 ± 7.3 vs. 18.8 ± 1.3 pg/ml, p < 0.001). Patients with low BMI had lower serum IL-10 than patients with normal BMI and large BMI – 31.0 ± 6.3 pg/ml; 76.7 ± 10.1 pg/ml; 117.7 ± 6.2 pg/ml, respectively (p < 0.001). Higher IL-10 was associated with increased serum albumin. Conclusion: Compensative increase of anti-inflammatory cytokine IL-10 in serum is typical in HD patients. Patients with nutrition deficit are characterized by lower serum IL-10.

Keywords

• haemodialysis, inflammation, nutrition, interleukin, IL-10, albumin