Photodynamic Therapy and Multi-Modality Imaging of Up-Conversion Nanomaterial Doped with AuNPs

Wei Zhang; Yanli Lu; Yang Zang; Jinhui Han; Qingyun Xiong; Jinping Xiong

doi:10.3390/ijms23031227

International Journal of Molecular Sciences (Jan 2022)

Photodynamic Therapy and Multi-Modality Imaging of Up-Conversion Nanomaterial Doped with AuNPs

Wei Zhang,
Yanli Lu,
Yang Zang,
Jinhui Han,
Qingyun Xiong,
Jinping Xiong

Affiliations

Wei Zhang: Beijing Key Laboratory of Electrochemical Process and Technology of Materials, School of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
Yanli Lu: Beijing Key Laboratory of Electrochemical Process and Technology of Materials, School of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
Yang Zang: Beijing Key Laboratory of Electrochemical Process and Technology of Materials, School of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
Jinhui Han: State Key Laboratory of Organic-Inorganic Composites, School of Chemical Engineering, School of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
Qingyun Xiong: Beijing Key Laboratory of Electrochemical Process and Technology of Materials, School of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
Jinping Xiong: Beijing Key Laboratory of Electrochemical Process and Technology of Materials, School of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China

DOI: https://doi.org/10.3390/ijms23031227
Journal volume & issue: Vol. 23, no. 3
p. 1227

Abstract

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Two key concerns exist in contemporary cancer chemotherapy in clinic: limited therapeutic efficiency and substantial side effects in patients. In recent years, researchers have been investigating a revolutionary cancer treatment technique, and photodynamic therapy (PDT) has been proposed by many scholars. A drug for photodynamic cancer treatment was synthesized using the hydrothermal method, which has a high efficiency to release reactive oxygen species (ROS). It may also be utilized as a clear multi-modality bioimaging platform for photoacoustic imaging (PAI) due to its photothermal effect, computed tomography (CT), and magnetic resonance imaging (MRI). When compared to single-modality imaging, multi-modality imaging delivers far more thorough and precise details for cancer diagnosis. Furthermore, Au-doped up-conversion nanoparticles (UCNPs) have an exceptionally high luminous intensity. The Au-doped UCNPs, in particular, are non-toxic to tissues without laser at an 808 nm wavelength, endowing the as-prepared medications with outstanding therapeutic efficacy but exceptionally low side effects. These findings may encourage fresh effective imaging-guided approaches to meet the goal of photodynamic cancer therapy to be created.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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