Estimation of serum lipid profile in patients with OSMF

Abstract

Aim: This study was done to evaluate the alteration in serum lipid profile pattern in patients with oral submucous fibrosis, with various histological grades of Oral Sub Mucous Fibrosis along with controls. Materials and Methods: The study included 150 participants, out of those 120 were having oral submucous fibrosis, and 30 cases of controls matched for age and sex were selected from the routine patients attending the Department of Oral Medicine and Radiology. Serum lipids, including total cholesterol (TC), LDL cholesterol (LDLC), HDL cholesterol (HDLC), VLDL cholesterol (VLDLC), and triglycerides (TG) were analyzed using kit ACCUREX [Bio-medicals limited, India] as per the instructions provided by manufacturer using SEMI AUTO ANALYSER [Tulip Coral 3000 Indian]. Statistical Analysis Used: Data were summarized as Mean ± SD (standard deviation). Groups were compared by Student's t-test. Groups were also compared by one way analysis of variance (ANOVA) and the significance of mean difference between (inter) the groups was done by Tukey's HSD (honestly significant difference) post hoc test after ascertaining normality by Shapiro–Wilk's test and homogeneity of variance between groups by Levene's test. A two-tailed (α = 2) P < 0.05 was considered statistically significant. Analyses were performed on SPSS software (windows version 17.0). Results: All the cholesterol showed a significant decrease in patients with OSMF than controls, and as the severity of disease increases the decrease in plasma lipid becomes more significant. Thus, this study proves the alteration in plasma lipid in patients with OSMF. Conclusions: This study concluded that the lower serum lipid levels may serve as a diagnostic indicator or marker in the early diagnosis of oral premalignant and malignant lesions.

Keywords

• HDL
• lipid profile
• OSMF
• VLDL