BASICS OF ANTIOXIDANT THERAPY IN ACUTE PANCREATITIS (experimental study)

Abstract

The activation of membrane lipid peroxidation, circulatory and tissue hypoxia are crucial triggers for membrane destroying events in acute pancreatitis. The use of anti-oxidant therapy in acute experimental pancreatitis reduces the intensity of lipid peroxidation (the level of diethenoid conjugates statistically confidently reduces by 30.4-32.5%) and restores the tissue respiration (oxidation-reduction potential is above the control one by 10-15%). Such therapy provides less effect on the microcirculation.

Keywords

• pancreatitis
• antioxidant
• hypoxia
• microcirculation
• lipid peroxidation