Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction

Soon-Jung Park; Ri Youn Kim; Bong-Woo Park; Sunghun Lee; Seong Woo Choi; Jae-Hyun Park; Jong Jin Choi; Seok-Won Kim; Jinah Jang; Dong-Woo Cho; Hyung-Min Chung; Sung-Hwan Moon; Kiwon Ban; Hun-Jun Park

doi:10.1038/s41467-019-11091-2

Nature Communications (Jul 2019)

Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction

Soon-Jung Park,
Ri Youn Kim,
Bong-Woo Park,
Sunghun Lee,
Seong Woo Choi,
Jae-Hyun Park,
Jong Jin Choi,
Seok-Won Kim,
Jinah Jang,
Dong-Woo Cho,
Hyung-Min Chung,
Sung-Hwan Moon,
Kiwon Ban,
Hun-Jun Park

Affiliations

Soon-Jung Park: Department of Medicine, Konkuk University School of Medicine
Ri Youn Kim: Department of Biomedical Sciences, City University of Hong Kong
Bong-Woo Park: Department of Medical Life Science, College of Medicine, The Catholic University of Korea
Sunghun Lee: Department of Biomedical Sciences, City University of Hong Kong
Seong Woo Choi: Department of Medicine, Konkuk University School of Medicine
Jae-Hyun Park: Division of Cardiology, Department of Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea
Jong Jin Choi: Department of Medicine, Konkuk University School of Medicine
Seok-Won Kim: Department of Mechanical Engineering, Pohang University of Science and Technology
Jinah Jang: Department of Creative IT Engineering and School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology
Dong-Woo Cho: Department of Mechanical Engineering, Pohang University of Science and Technology
Hyung-Min Chung: Department of Medicine, Konkuk University School of Medicine
Sung-Hwan Moon: Department of Medicine, Konkuk University School of Medicine
Kiwon Ban: Department of Biomedical Sciences, City University of Hong Kong
Hun-Jun Park: Department of Medical Life Science, College of Medicine, The Catholic University of Korea

DOI: https://doi.org/10.1038/s41467-019-11091-2
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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Myocardial infarction causes damage to the myocardium and vasculature. Here the authors show in a rat model of myocardial infarction that cardiomyocytes derived from human induced pluripotent stem cells combined with a human mesenchymal stem cell-loaded patch lead to improved cardiac function and promote vessel formation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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