miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes

Martin G. Scherm; Isabelle Serr; Adam M. Zahm; Jonathan Schug; Saverio Bellusci; Rossella Manfredini; Victoria K. Salb; Katharina Gerlach; Benno Weigmann; Anette-Gabriele Ziegler; Klaus H. Kaestner; Carolin Daniel

doi:10.1038/s41467-019-13587-3

Nature Communications (Dec 2019)

miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes

Martin G. Scherm,
Isabelle Serr,
Adam M. Zahm,
Jonathan Schug,
Saverio Bellusci,
Rossella Manfredini,
Victoria K. Salb,
Katharina Gerlach,
Benno Weigmann,
Anette-Gabriele Ziegler,
Klaus H. Kaestner,
Carolin Daniel

Affiliations

Martin G. Scherm: Institute of Diabetes Research, Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München
Isabelle Serr: Institute of Diabetes Research, Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München
Adam M. Zahm: Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania
Jonathan Schug: Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania
Saverio Bellusci: German Center for Lung Research, Excellence Cluster Cardio-Pulmonary System, Universities of Giessen and Marburg Lung Center
Rossella Manfredini: Center for Regenerative Medicine, University of Modena and Reggio Emilia
Victoria K. Salb: Institute of Diabetes Research, Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München
Katharina Gerlach: Department of Medicine 1, University of Erlangen-Nuremberg
Benno Weigmann: Department of Medicine 1, University of Erlangen-Nuremberg
Anette-Gabriele Ziegler: Institute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health
Klaus H. Kaestner: Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania
Carolin Daniel: Institute of Diabetes Research, Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München

DOI: https://doi.org/10.1038/s41467-019-13587-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

Read online

miRNA142-3p and Tet2 are separately known to regulate Treg. Here the authors show that miRNA142-3p targets Tet2 and by this opposes Treg differentiation in autoimmune diabetes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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