Vaccines (Oct 2023)

Novel Influenza Vaccines: From Research and Development (R&D) Challenges to Regulatory Responses

  • Xiangchuan He,
  • Tianxiang Zhang,
  • Shitong Huan,
  • Yue Yang

DOI
https://doi.org/10.3390/vaccines11101573
Journal volume & issue
Vol. 11, no. 10
p. 1573

Abstract

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Influenza vaccines faced significant challenges in achieving sufficient protective efficacy and production efficiency in the past. In recent decades, novel influenza vaccines, characterized by efficient and scalable production, advanced platforms, and new adjuvant technologies, have overcome some of these weaknesses and have been widely licensed. Furthermore, researchers are actively pursuing the development of next-generation and universal influenza vaccines to provide comprehensive protection against potential pandemic subtypes or strains. However, new challenges have emerged as these novel vaccines undergo evaluation and authorization. In this review, we primarily outline the critical challenges and advancements in research and development (R&D) and highlight the improvements in regulatory responses for influenza vaccines.

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