EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth

Abstract

EGFR signalling is required for oncogenic Ras driven tumorigenesis. In this study, using aDrosophilatumour model the authors demonstrate that depletion of Arf6, a Ras-related GTP-binding protein activated by EGFR, supresses oncogenic Ras driven overgrowth via modulation of Hedgehog signalling.