Journal of Pharmacological Sciences (Dec 2018)

SBF-1 preferentially inhibits growth of highly malignant human liposarcoma cells

  • Wei Chen,
  • Xuelong Qian,
  • Yue Hu,
  • Wei Jin,
  • Yunlong Shan,
  • Xianying Fang,
  • Yang Sun,
  • Biao Yu,
  • Qiong Luo,
  • Qiang Xu

Journal volume & issue
Vol. 138, no. 4
pp. 271 – 278

Abstract

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Frequent local recurrence and metastasis are generally involved in human liposarcoma, but the management is a challenge. There is an urgent need for improved effective therapy. In the present study, we reported that SBF-1, a steroidal glycoside, inhibited the growth of cultured highly malignant human liposarcoma SW872-S cells in vitro and in vivo. SBF-1 down-regulated the phosphorylation of protein kinase B (AKT) and thus reduced cell adhesion to fibronectin and laminin. Then we found that SBF-1 inhibited the expression of oxysterol binding protein (OSBP) in SW872-S cells, indicating that OSBP may be involved in malignant liposarcoma cell survival. Cancer cell growth and AKT phosphorylation were inhibited significantly upon knockdown of OSBP in SW872-S cells in vitro. Taken together, these results suggest that SBF-1 causes an apparent loss of OSBP function in SW872-S cells, resulting in growth inhibition. Based on our findings, OSBP serves as a potential therapeutic target for human liposarcoma. Keywords: SBF-1, Malignant liposarcoma, SW872-S